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Dr. Andy Mitchell

Professor, Organic Chemistry; Associate Chair of Graduate Studies
Science Laboratory Building - SLB 219
Office Hours
Mon., Tues. & Wed. 2:30-3:30 p.m.
  • About
  • Education
  • Awards & Honors
  • Research


Andy Mitchell obtained a B.S. in Chemistry at Grove City College (PA) in 2001. He joined the research group of Prof. Daniel Romo at Texas A&M University and completed his Ph.D. in 2008. After two years as a postdoctoral associate with Prof. Jeffrey W. Bode at the University of Pennsylvania, he joined the Department of Chemistry at Illinois State University as an Assistant Professor in 2010 and was promoted to Associate Professor with Tenure in 2016 and promoted to Professor in 2021.

Current Courses

299.015Independent Honor Study In Chemistry

499.015Independent Research For The Master's Thesis

231.005Organic Chemistry Laboratory I

426.001Organic Synthesis

290.015Research in Chemistry

490.015Research In Chemistry

499.115Independent Research For The Master's Thesis Last Term

290.001Research in Chemistry

490.009Research In Chemistry

Teaching Interests & Areas

Organic Chemistry

Research Interests & Areas

Often referred to as the central science, chemistry continues to demonstrate utility toward a wide range of scientific disciplines. The development of new reactions occupies a privileged position within the field of chemistry due to extensive applications derived from organic synthesis. Since pioneering syntheses of urea (1828) and acetic acid (1845), organic synthesis has impacted countless technological advances. The theme of our research program is natural product inspired organic synthesis - an enduring training ground for next generation scientists. Our group focuses on the development of new reactions that are either inspired by or directed toward natural products. Several oxidopyrylium-alkene [5+2] cycloadditions are under investigation since the products, bridged polycyclic ethers, are ubiquitous moieties in biologically active natural products. Students learn a variety of skills in this research including laboratory techniques, mechanistic reasoning, interpretation of spectra, and presentation of results.

Ph D Chemistry

Texas A&M University
College Station, TX 77840

BS Chemistry

Grove City College
Grove City, PA 16127

Research Grant – Chemical Synthesis (RUI) – CHE-1954588

National Science Foundation

Early Career Chemist Award

American Chemical Society Illinois Heartland Local Section

Research Grant – Chemical Synthesis (RUI) – CHE-1565644

National Science Foundation

Red Tassel Mortar Board Faculty Appreciation Award

Illinois State University

University Research Initiative Award

Illinois State University

Major Research Instrumentation Award (Co-PI) – CHE-1337497

National Science Foundation

University Research Grant, Faculty Research Award

Illinois State University

Cottrell College Science Award

Research Corporation for Science Advancement

Undergraduate New Investigator Grant

American Chemical Society Petroleum Research Fund

University Research Grant, Pre-Tenure Faculty Initiative

Illinois State University

Journal Article

Grabowski, J., Ferrence, G., & Mitchell, T. Efforts toward the total synthesis of (±)-toxicodenane A utilizing an oxidopyrylium-based [5 + 2] cycloaddition of a silicon-tethered BOC-pyranone. Tetrahedron Letters 61 (2020): 152324.
Grabowski, Jacob P.; Ferrence, Gregory M.; Mitchell T. Andrew “Efforts toward the total synthesis of (±)-toxicodenane A utilizing an oxidopyrylium-based [5+2] cycloaddition of a silicon-tethered BOC-pyranone,” Tetrahedron Letters 2020, 61(36), 152324. DOI: 10.1016/j.tetlet.2020.152324.
Rokey, S., Simanis, J., Chunyin, L., Pohani, S., Behrends, S., Bulandr, J., Ferrence, G., Goodell, J., & Mitchell, T. Intramolecular asymmetric oxidopyrylium-based [5 + 2] cycloadditions. Tetrahedron Letters 61 (2020): 152377.
Rokey, Samantha N.; Simanis, Justin A.; Law, Chunyin M.; Pohani, Shilpa; Willens Behrends, Samantha; Bulandr, Jacob J.; Ferrence, Gregory M.; Goodell, John R.; Andrew Mitchell, T. “Intramolecular asymmetric oxidopyrylium-based [5 + 2] cycloadditions,” Tetrahedron Letters 2020, 61(41), 152377. DOI: 10.1016/j.tetlet.2020.152377.
Bulandr, J., Grabowski, J., Law, C., Shaw, J., Goodell, J., & Mitchell, T. Investigation of Transfer Group, Tether Proximity and Alkene Substitution for Intramolecular Silyloxypyrone-Based [5 + 2] Cycloadditions. Journal of Organic Chemistry 84 (2019): 10306-10320.


Angles, S. N.; Guo, W.; Darko, K.; Erzuah, M.; Pauley, K. G.; Promise, I. E.; Goodell, J. R.; Tantillo, D. J.; Mitchell, T. A. Net Intermolecular Silyloxypyrone-based (5 + 2) Cycloadditions Utilizing Amides as Enabling and Cleavable Tethers. Org. Lett. 2023, 25, 7137-7141.
Youman, A. J.; Rokey, S. N.; Grabowski, J. P.; Guo, W.; Sun, Q.; Angles, S. N.; Goodell, J. R.; Tantillo, D. J.; Mitchell, T. A. Experimental and Theoretical Investigation of the Synchronicity of Ambident Silyloxypyrone-based (5 + 2) Cycloadditions. J. Org. Chem. 2023, 88, 5972-5981.
Tetrahedron Lett. 2022, 107, 154094

Grants & Contracts

Silyloxypyrone-Based [5+2] Cycloadditions: Mechanism, Methods, and Mentorship. National Science Foundation (RUI): CHE-1954588. Federal. (2020)
Exploration of Cycloadditions toward Novel Heterocyclic Scaffolds. National Science Foundation (RUI): CHE-1565644. Federal. (2016)
Stereoselective N-Heterocyclic Carbene (NHC): Catalyzed Oxidopyrylium-Enolate [5+2] Cycloadditions toward Bridged, Polycyclic Ethers. American Chemical Society - Petroleum Research Foundation (UNI). Private. (2012)
Toward the Building Blocks for the Convergent Total Synthesis of Muironolide A. Research Corporation for Science Advancement (Cottrell College Award). Private. (2012)