Dr. Mohamed Eldeeb
Assistant Professor-Biochemistry
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Office
SLB Science Laboratory Building 318
Office Hours
Wed. 11-12:30; or by appt.
Office Phone
Email
- About
- Awards & Honors
- Selected Research
Biography
Dr. Eldeeb is an Assistant Professor of Biochemistry at ISU. Dr. Eldeeb obtained his PhD in Biochemistry from the University of Alberta, Canada, where he studied the roles of protein degradation in regulating cell-death signaling. He did his postdoctoral research at McGill University. Dr. Eldeeb's current research aims to mechanistically understand signaling molecules that guide protein degradation, mitochondrial degradation and cell death decisions in response to stress signals.
Current Courses
CHE 343.001 Biochemistry Laboratory
CHE 343.002 Biochemistry Laboratory
CHE 343.003 Biochemistry Laboratory
BSC 299.060 Independent Honor Study
CHE 299.016 Independent Honor Study In Chemistry
CHE 499.016 Independent Research For The Master's Thesis
BSC 290.060 Research In Biological Sciences
CHE 290.016 Research in Chemistry
CHE 490.016 Research In Chemistry
Research Interests & Areas
Research in my group aspires to discover and mechanistically understand signaling molecules that regulate protein degradation, mitochondrial degradation and cell death decisions in response to various stress and metabolic signals. Our group asks fundamental questions about the journey of proteins – how do proteins live and die, and how do these processes affect the cell life and death decisions? Our work uses a combination of biochemical, molecular, cellular and genetic approaches to try to answer these questions. Our discoveries help create a better molecular understanding of neurodegenerative diseases and other aging-associated disorders.
Banting Fellowship
CIHR
2020
Basic Research Fellowship
Parkinson Canada
2018
75th Anniversary Scholarship
University of Alberta Faculty of Medicine
2016
Travel Award
American Society of Biochemistry and Molecular Biology
2016
Alberta Innovates-Technology Futures Graduate Scholarship
Alberta Innovates-Technology Futures
2014
Doctoral Recruitment Scholarship
University of Alberta
2011
Lionel B Pett Academic Excellence Graduate Award
University of Alberta
2011
Cairo University Graduate Excellence Award
Cairo University
2010
Zoology Department Excellence Award
Cairo University
2010
Prof. El Halafawy Excellence Award
Cairo University
2008
Journal Article
Mitochondrial import stress and PINK1-mediated mitophagy: the role of the PINK1-TOMM-TIMM23 supercomplex.
Mohamed Eldeeb, A Fallahi, A Soumbasis, A N Bayne, J F Trempe, E A Fon.
Autophagy, 20 (8), 1903-1905, (2024), 10.1080/15548627.2024.2340399
How does mitochondrial import machinery fine-tune mitophagy? Different paths and one destination.
Mohamed Eldeeb, A Soumbasis, E A Fon.
Trends in endocrinology and metabolism: TEM, 34 (8), 427-429, (2023), 10.1016/j.tem.2023.05.005
N-degron-mediated degradation of the proteolytically activated form of PKC-theta kinase attenuates its pro-apoptotic function.
Mohamed Eldeeb, W Zhou, M Esmaili, A M Elgohary, H Wei, R P Fahlman.
Cellular signalling, 110, 110830, (2023), 10.1016/j.cellsig.2023.110830
A molecular dialogue between local translation and mitochondria: powering mitophagy in axons.
A Soumbasis, Mohamed Eldeeb.
Molecular biology reports, 49 (9), 9013-9016, (2022), 10.1007/s11033-022-07708-3
Dephosphorylation Targeting Chimaera (DEPTAC): Targeting Tau Proteins in Tauopathies.
A Soumbasis, Mohamed Eldeeb, M A Ragheb, C E Zorca.
Current protein & peptide science, 23 (3), 129-132, (2022), 10.2174/1389203723666220519154229
Hallmarks and Molecular Tools for the Study of Mitophagy in Parkinson's Disease.
T Goiran, Mohamed Eldeeb, C E Zorca, E A Fon.
Cells, 11 (13), (2022), 10.3390/cells11132097
Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex.
S Rasool, S Veyron, N Soya, Mohamed Eldeeb, G L Lukacs, E A Fon, J F Trempe.
Molecular cell, 82 (1), 44-59.e6, (2022), 10.1016/j.molcel.2021.11.012
Mitochondrial quality control in health and in Parkinson's disease.
Mohamed Eldeeb, Roger Thomas, M A Ragheb, A Fallahi, E A Fon.
Physiological reviews, 102 (4), 1721-1755, (2022), 10.1152/physrev.00041.2021
Multifaceted targeted protein degradation systems for different cellular compartments.
C E Zorca, A Fallahi, S Luo, Mohamed Eldeeb.
BioEssays : news and reviews in molecular, cellular and developmental biology, 44 (6), e2200008, (2022), 10.1002/bies.202200008
Regulation of Neurodegeneration-associated Protein Fragments by the N-degron Pathways.
Mohamed Eldeeb, M A Ragheb, M H Soliman, R P Fahlman.
Neurotoxicity research, 40 (1), 298-318, (2022), 10.1007/s12640-021-00396-0
The Role of PTEN-L in Modulating PINK1-Parkin-Mediated Mitophagy.
Mohamed Eldeeb, M Esmaili, Mk Hassan, M A Ragheb.
Neurotoxicity research, 40 (4), 1103-1114, (2022), 10.1007/s12640-022-00475-w
Current Developments in Native Nanometric Discoidal Membrane Bilayer Formed by Amphipathic Polymers.
M Esmaili, Mohamed Eldeeb, A A Moosavi-Movahedi.
Nanomaterials (Basel, Switzerland), 11 (7), (2021), 10.3390/nano11071771
Fine-tuning ER-phagy by post-translational modifications.
Mohamed Eldeeb, C E Zorca, M A Ragheb, F B Rashidi, D S Salah El-Din.
BioEssays : news and reviews in molecular, cellular and developmental biology, 43 (2), e2000212, (2021), 10.1002/bies.202000212
N-Terminal-Dependent Protein Degradation and Targeting Cancer Cells.
Mohamed Eldeeb.
Anti-cancer agents in medicinal chemistry, 21 (2), 231-236, (2021), 10.2174/1871520620666200819112632
ER-associated Protein Degradation at Atomic Resolution.
Mohamed Eldeeb, R P Fahlman, M Michalak.
Trends in biochemical sciences, 45 (9), 723-725, (2020), 10.1016/j.tibs.2020.06.005
Extracellular protein degradation via the lysosome.
Mohamed Eldeeb, C E Zorca, T Goiran.
Communications chemistry, 3 (1), 149, (2020), 10.1038/s42004-020-00397-8
Fine-Tuning TOM-Mitochondrial Import via Ubiquitin.
Mohamed Eldeeb, A N Bayne, J F Trempe, E A Fon.
Trends in cell biology, 30 (6), 425-427, (2020), 10.1016/j.tcb.2020.04.007
How does protein degradation regulate TOM machinery-dependent mitochondrial import?
Mohamed Eldeeb, M A Ragheb, M Esmaili.
Current genetics, 66 (3), 501-505, (2020), 10.1007/s00294-020-01056-0
N-degron-mediated degradation and regulation of mitochondrial PINK1 kinase.
Mohamed Eldeeb, M A Ragheb.
Current genetics, 66 (4), 693-701, (2020), 10.1007/s00294-020-01062-2
Physiological State Dictates the Proteasomal-Mediated Purging of Misfolded Protein Fragments.
Mohamed Eldeeb, M A Ragheb, M Esmaili, F Hussein.
Protein and peptide letters, 27 (3), 251-255, (2020), 10.2174/0929866526666191026111951
Targeting Cancer Cells via N-degron-based PROTACs.
Mohamed Eldeeb, C E Zorca, R P Fahlman.
Endocrinology, 161 (12), (2020), 10.1210/endocr/bqaa185
A molecular toolbox for studying protein degradation in mammalian cells.
Mohamed Eldeeb, R Siva-Piragasam, M A Ragheb, M Esmaili, M Salla, R P Fahlman.
Journal of neurochemistry, 151 (4), 520-533, (2019), 10.1111/jnc.14838
Beyond ER: Regulating TOM-Complex-Mediated Import by Ubx2.
Mohamed Eldeeb, E J MacDougall, M A Ragheb, E A Fon.
Trends in cell biology, 29 (9), 687-689, (2019), 10.1016/j.tcb.2019.07.003
Cell Death: N-degrons Fine-Tune Pyroptotic Cell Demise.
Mohamed Eldeeb, M A Ragheb, E A Fon.
Current biology : CB, 29 (12), R588-R591, (2019), 10.1016/j.cub.2019.05.004
Does N-Terminal Protein Acetylation Lead to Protein Degradation?
Mohamed Eldeeb, R P Fahlman, M A Ragheb, M Esmaili.
BioEssays : news and reviews in molecular, cellular and developmental biology, 41 (11), e1800167, (2019), 10.1002/bies.201800167
Formylation of Eukaryotic Cytoplasmic Proteins: Linking Stress to Degradation.
Mohamed Eldeeb, R P Fahlman, M Esmaili, E A Fon.
Trends in biochemical sciences, 44 (3), 181-183, (2019), 10.1016/j.tibs.2018.12.008
Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson's disease.
V M Fava, Y Z Xu, G Lettre, N Van Thuc, M Orlova, V H Thai, S Tao, N Croteau, Mohamed Eldeeb, E J MacDougall, G Cambri, R Lahiri, Lori J Adams, E A Fon, J F Trempe, A Cobat, A Alcaïs, L Abel, E Schurr.
Proceedings of the National Academy of Sciences of the United States of America, 116 (31), 15616-15624, (2019), 10.1073/pnas.1901805116
When Degradation Elicits the Alarm: N-Terminal Degradation of NLRP1B Unleashes Its Inflammasome Activity.
Mohamed Eldeeb, R P Fahlman, M Esmaili, E A Fon.
Molecular cell, 74 (4), 637-639, (2019), 10.1016/j.molcel.2019.04.032
Does Too Much MAGIC Lead to Mitophagy?
Mohamed Eldeeb, R P Fahlman.
Trends in biochemical sciences, 43 (7), 485-487, (2018), 10.1016/j.tibs.2018.04.008
Emerging branches of the N-end rule pathways are revealing the sequence complexities of N-termini dependent protein degradation.
Mohamed Eldeeb, Leitao LCA, R P Fahlman.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 96 (3), 289-294, (2018), 10.1139/bcb-2017-0274
Post-translational N-terminal Arginylation of Protein Fragments: A Pivotal Portal to Proteolysis.
Mohamed Eldeeb, M A Ragheb.
Current protein & peptide science, 19 (12), 1214-1223, (2018), 10.2174/1389203719666180809113122
Regulating Apoptosis by Degradation: The N-End Rule-Mediated Regulation of Apoptotic Proteolytic Fragments in Mammalian Cells.
Mohamed Eldeeb, R P Fahlman, M Esmaili, M A Ragheb.
International journal of molecular sciences, 19 (11), (2018), 10.3390/ijms19113414
Proteomic characterization of EL4 lymphoma-derived tumors upon chemotherapy treatment reveals potential roles for lysosomes and caspase-6 during tumor cell death in vivo.
D A Kramer, Mohamed Eldeeb, M Wuest, J Mercer, R P Fahlman.
Proteomics, 17 (12), (2017), 10.1002/pmic.201700060
Phosphorylation Impacts N-end Rule Degradation of the Proteolytically Activated Form of BMX Kinase.
Mohamed Eldeeb, R P Fahlman.
The Journal of biological chemistry, 291 (43), 22757-22768, (2016), 10.1074/jbc.M116.737387
The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway.
Mohamed Eldeeb, R P Fahlman.
Oncotarget, 5 (9), 2714-22, (2014), 10.18632/oncotarget.1931
Other
COVID-19 infection may increase the risk of parkinsonism - Remember the Spanish flu?
Mohamed Eldeeb, F S Hussain, Z A Siddiqi.
Cytokine & growth factor reviews, 54, 6-7, (2020), 10.1016/j.cytogfr.2020.06.009