Dr. Kyle Floyd
Assistant Professor of Microbiology
Office
SLB Science Laboratory Building 346
Office Hours
By appointment.
Office Phone
Email
- About
- Education
- Awards & Honors
- Selected Research
Current Courses
BSC 499.011 Independent Research For The Master's Thesis
BSC 499.029 Independent Research For The Master's Thesis
BSC 290.015 Research In Biological Sciences
BSC 599.011 Research In The Biological Sciences
BSC 299.013 Independent Honor Study
BSC 499.011 Independent Research For The Master's Thesis
BSC 499.029 Independent Research For The Master's Thesis
BSC 260.001 Microbiology
BSC 290.015 Research In Biological Sciences
BSC 599.029 Research In The Biological Sciences
Teaching Interests & Areas
Microbiology, Molecular Biology, Biotechnology
Research Interests & Areas
My lab is interested in the dynamics of bacterial surface attachment, mediated by adhesive macromolecular structures known as pili, which underly biofilm formation and bacterial pathogenesis. Our research seeks to understand how the facultative human pathogen and causative agent of the gastrointestinal disease cholera, Vibrio cholerae, regulates surface adhesion to mediate both environmental and host colonization.
Post-Doc Microbiology
University of California - Santa Cruz
Santa Cruz, CA
PhD Microbiology and Immunology
Vanderbilt University
Nashville, TN
MS Public Health
University of Alabama - Birmingham
Birmingham, AL
BS Biology
Berry College
Mount Berry, GA
University Research Initiative Award
Illinois State University
2025
Journal Article
Independent validation of transgenerational inheritance of learned pathogen avoidance in Caenorhabditis elegans
Aalimah Akinosho, Joseph Alexander, Kyle Floyd, Andres Gabriel Vidal-Gadea.
eLife, 14, (2025), 10.7554/elife.107034
Vibrio cholerae biofilm matrix assembly and growth are shaped by a glutamate-specific TAXI/TRAP protein.
A Potapova, R Oguchi, S Jimmy, C R Evans, K D Yarrington, J B Winans, S Piepoli, E A Older, O F Schakel, M T Wetherington, W Garvey, Kyle Floyd, E Vinogradov, P J Yunker, L M Sanchez, C D Nadell, D H Limoli, Dietrich LEP, H Sondermann, F H Yildiz.
Proceedings of the National Academy of Sciences of the United States of America, 122 (50), e2504869122, (2025), 10.1073/pnas.2504869122
Outer membrane vesicles and the outer membrane protein OmpU govern Vibrio cholerae biofilm matrix assembly.
A Potapova, W Garvey, P Dahl, S Guo, Y Chang, C Schwechheimer, M A Trebino, Kyle Floyd, B S Phinney, J Liu, N S Malvankar, F H Yildiz.
mBio, 15 (2), e0330423, (2024), 10.1128/mbio.03304-23
Nitric oxide stimulates type IV MSHA pilus retraction in Vibrio cholerae via activation of the phosphodiesterase CdpA.
H Q Hughes, Kyle Floyd, S Hossain, S Anantharaman, D T Kysela, M Zöldi, L Barna, Y Yu, M P Kappler, T N Dalia, R C Podicheti, D B Rusch, M Zhuang, C L Fraser, Y V Brun, S C Jacobson, J B McKinlay, F H Yildiz, E M Boon, A B Dalia.
Proceedings of the National Academy of Sciences of the United States of America, 119 (7), (2022), 10.1073/pnas.2108349119
Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation.
Wong GCL, J D Antani, P P Lele, J Chen, B Nan, M J Kühn, A Persat, J L Bru, N M Høyland-Kroghsbo, A Siryaporn, J C Conrad, F Carrara, Y Yawata, R Stocker, Y Brun, G B Whitfield, C K Lee, J de Anda, W C Schmidt, R Golestanian, G A O'Toole, Kyle Floyd, F H Yildiz, S Yang, F Jin, M Toyofuku, L Eberl, N Nomura, L A Zacharoff, M Y El-Naggar, S E Yalcin, N S Malvankar, M D Rojas-Andrade, A I Hochbaum, J Yan, H A Stone, N S Wingreen, B L Bassler, Y Wu, H Xu, K Drescher, J Dunkel.
Physical biology, 18 (5), (2021), 10.1088/1478-3975/abdc0e
A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae.
C Schwechheimer, K Hebert, S Tripathi, P K Singh, Kyle Floyd, E R Brown, M E Porcella, J Osorio, Kiblen JTM, F A Pagliai, K Drescher, S M Rubin, F H Yildiz.
PLoS pathogens, 16 (8), e1008745, (2020), 10.1371/journal.ppat.1008745
Reciprocal c-di-GMP signaling: Incomplete flagellum biogenesis triggers c-di-GMP signaling pathways that promote biofilm formation.
D C Wu, D Zamorano-Sánchez, F A Pagliai, J H Park, Kyle Floyd, C K Lee, G Kitts, C B Rose, E M Bilotta, Wong GCL, F H Yildiz.
PLoS genetics, 16 (3), e1008703, (2020), 10.1371/journal.pgen.1008703
c-di-GMP modulates type IV MSHA pilus retraction and surface attachment in Vibrio cholerae.
Kyle Floyd, C K Lee, W Xian, M Nametalla, A Valentine, B Crair, S Zhu, H Q Hughes, J L Chlebek, D C Wu, J Hwan Park, A M Farhat, C J Lomba, C K Ellison, Y V Brun, J Campos-Gomez, A B Dalia, J Liu, N Biais, Wong GCL, F H Yildiz.
Nature communications, 11 (1), 1549, (2020), 10.1038/s41467-020-15331-8
Biofilm Formation by Uropathogenic Escherichia coli Is Favored under Oxygen Conditions That Mimic the Bladder Environment.
A R Eberly, Kyle Floyd, C J Beebout, S J Colling, M J Fitzgerald, C W Stratton, J E Schmitz, M Hadjifrangiskou.
International journal of molecular sciences, 18 (10), (2017), 10.3390/ijms18102077
A cell-based systems biology assessment of human blood to monitor immune responses after influenza vaccination.
K L Hoek, P Samir, L M Howard, X Niu, N Prasad, A Galassie, Q Liu, T M Allos, Kyle Floyd, Y Guo, Y Shyr, S E Levy, S Joyce, Keri Edwards, A J Link.
PloS one, 10 (2), e0118528, (2015), 10.1371/journal.pone.0118528
A method to prevent protein delocalization in imaging mass spectrometry of non-adherent tissues: application to small vertebrate lens imaging.
D M Anderson, Kyle Floyd, S Barnes, J M Clark, J I Clark, H Mchaourab, K L Schey.
Analytical and bioanalytical chemistry, 407 (8), 2311-20, (2015), 10.1007/s00216-015-8489-5
Adhesive fiber stratification in uropathogenic Escherichia coli biofilms unveils oxygen-mediated control of type 1 pili.
Kyle Floyd, J L Moore, A R Eberly, J A Good, C L Shaffer, H Zaver, F Almqvist, E P Skaar, R M Caprioli, M Hadjifrangiskou.
PLoS pathogens, 11 (3), e1004697, (2015), 10.1371/journal.ppat.1004697
The yin-yang driving urinary tract infection and how proteomics can enhance research, diagnostics, and treatment.
Kyle Floyd, A E Meyer, G Nelson, M Hadjifrangiskou.
Proteomics. Clinical applications, 9 (11-12), 990-1002, (2015), 10.1002/prca.201500018
Genistein and genistein-containing dietary supplements accelerate the early stages of cataractogenesis in the male ICR/f rat.
Kyle Floyd, D R Stella, C C Wang, S Laurentz, G P McCabe, O P Srivastava, S Barnes.
Experimental eye research, 92 (2), 120-7, (2011), 10.1016/j.exer.2010.12.006
Tissue localization and solubilities of αA-crystallin and its numerous C-terminal truncation products in pre- and postcataractous ICR/f rat lenses.
D R Stella, Kyle Floyd, A C Grey, M B Renfrow, K L Schey, S Barnes.
Investigative ophthalmology & visual science, 51 (10), 5153-61, (2010), 10.1167/iovs.10-5302