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Dr. Craig Gatto

Interim chair of chemistry
Julian Hall - JH 210C
  • About
  • Education
  • Awards & Honors
  • Research

Research Interests & Areas

The active transport of ions across cell membranes is performed by P-type ATPases. These are integral membrane proteins which use the energy of hydrolysis of ATP to pump ions across biological membranes. The mechanism by which these proteins couple ATP hydrolysis to ion transport is one of the central interests of the laboratory. My laboratory focuses on structure-function studies, molecular mechanism, assembly and subcellular trafficking of these important transporters. P-type pumps are tansiently phosphorylated from ATP and transport alkali metals (e.g. Na+, K+, H+, Ca2+) as well as heavy metals (e.g Cu2+ and Cd2+). Members of this protein superfamily are represented across all phyla.

Ph D Physiology

University of Missouri-Columbia
Columbia MO

MS Zoology

Eastern Illinois University
Charleston, IL

BS Zoology

Eastern Illinois University
Charleston, IL

University Professor

Illinois State University

Outstanding University Researcher Award

Illinois State University

Faculty Star

ISU Men's Basketball game

2008 Class of Outstanding Graduate Alumni

Eastern Illinois University Graduate School

Outstanding College Researcher Award

Illinois State University

Outstanding College Service Award

College of Arts and Sciences

University Research Initiative Award

Illinois State University

James Metcalfe Outstanding Reserach Proposal

American Heart Association

James Metcalfe Outstanding Reserach Proposal

American Heart Association

Student Reseracher Award

University of Missouri-Columbia

Instructor's Manual

Reifenberger, M., Arnett, K., Gatto, C., & Milanick, M. The reactive nitrogen species peroxynitrite is a potent inhibitor of renal Na,K-ATPase activity. Am. J. Physiol. -Renal Physiol 295 (2008): 1191-1198.

Journal Article

K.B. Tiwari, C. Gatto, and B.J. Wilkinson. Plasticity of Coagulase-Negative Staphylococcal Membrane Fatty Acid Composition and Implications for Responses to Antimicrobial Agents. Antibiotics. 9(214), 1 – 10, 2020.
K.M. Hines, G. Alvarado, X. Chen, C. Gatto, A. Pokorny, F. Alonzo III, B.J. Wilkinson, and L. Xu. Lipidomic and Ultrastructural Characterization of Cell Envelope of Staphylococcus aureus Grown in the Presence of Human Serum. mSphere. 5(3), 339-355, 2020.
Meyer, D., Bijlani, S., DeSautu, M., Young, V., Spontarelli, K., Gatto, C., & Artigas, P. FXYD protein isoforms differentially modulate human Na/K pump function. 152.12 (2020): 660-672.
Singh, V., Sirobhushanam, S., Ring, R., Singh, S., Gatto, C., & Wilkinson, B. Roles of pyruvate dehydrogenase and branched-chain α-keto acid dehydrogenase in branched-chain membrane fatty acid levels and associated functions in Staphylococcus aureus.. Journal of medical microbiology 67.4 (2018): 570-578.
Stanley, K., Young, V., Gatto, C., & Artigas, P. External Ion Access in the Na/K Pump: Kinetics of Na<sup>+</sup>, K<sup>+</sup>, and Quaternary Amine Interaction.. Biophysical journal 115.2 (2018): 361-374.


Altered transport in Na/K pumps with -subunits truncated at its 5 C-terminal residues. Experimental Biology. Experimental Biology. (2009)
Deciphering the molecular mechanism of active transport via P-type ATPases. School of Biological Sciences Seminar Series. School of Biological Sciences; Illinois State University. (2009)
β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) of Listeria monocytogenes has Increased Preference for the Precursor of Anteiso Fatty Acids over Iso Branched-Chain Fatty Acid Precursors at Low Temperature. 109th General Meeting of the American Society for Microbiology. American Society of Microbiology. (2009)
Cellular Differences between the Tomato Plant SERCA Ortholog, LCA, Compared to its Vertebrate Counterparts. 12th International Meeting on P-type ATPases. (2008)
Deciphering the molecular mechanism of active transport via P-type ATPases. Department of Physics Seminar. Department of Physics. Illinois State University. (2008)
Expression Pattern of Fluorescently Tagged Na pump in C. elegans. Biophysical Society Meeting. Biophysical Society. (2008)
Extracellular protons alter cation binding to the red cell Na,K-ATPase. Red Cell Conference. University of Rochester. (2008)
Functional differences between plant and animal ER-type Ca-ATPases. Centre for Membrane Pumps in Cells and Disease, Dept. of Molecular Biology Seminar. Centre for Membrane Pumps in Cells and Disease, Dept. of Molecular Biology, University of Aarhus. (2008)
In vivo monitoring of Na,K-ATPase trafficking in polarized epithelium. Annual Biomedical Research Conference for Minority Students. (2008)
Pharmacological dissection of the Na pump molecular mechanism. Dept. of Molecular Physiology & Biophysics Seminar. Dept. of Molecular Physiology & Biophysics, Texas Tech University Health Sciences Center. (2008)

Grants & Contracts

Cell Physiology of the Na,K-ATPase. National Institutes of Health. Federal. (2016)
Branched-chain fatty acids and membrane function in Listeria monocytogenes. National Institutes of Health. Federal. (2013)
Cellular structure-function of Na pump Assembly-. National Institutes of Health- R15. Federal. (2009)
Role for Na,K-ATPase in Nucleoplasmic Ca Homeostasis. National Institutes of Health- R21. Federal. (2009)
Experiment (2008)