Dr. Brian Wilkinson
Distinguished Professor Emeritus
Office
SLB Science Laboratory Building 427
Office Hours
M-F 9-5
Office Phone
Email
- About
- Education
- Selected Research
Biography
Professor of Microbiology working on Staphylococcus aureus antibiotic resistance and Listeria monocytogenes working on low temperature growth
Ph D Microbiology
University of Sheffield
Grants and Contracts
Branched-chain fatty acids and membrane function in Listeria monocytogenes
Craig Gatto, Brian James Wilkinson.
National Institutes of Health. September 1 2013 - August 31 2016
Branched-chain fatty acids and membrane function in Listeria monocytogenes
Brian James Wilkinson.
National Insitutes of Health- R15. September 01 2012 - August 31 2015
Extension to studies of decreased susceptibility to telavancin
Brian James Wilkinson.
Astellas Pharma US. March 2010 - February 2011
Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Telavancin
Radheshyam Jayaswal, Brian James Wilkinson.
Astellas Pharma US Inc. January 1 2009 - January 1 2010
Membrane fluidity and S. aureus antimicrobial susceptibility
Brian James Wilkinson.
National Institutes of Health-R15. October 2009 - September 2012
A switch from the hVISA to the VISA mechanism
Brian James Wilkinson.
National Institutes of Health. May 2008 - May 2012
Mode of action of Daptomycin
Radheshyam Jayaswal, Brian James Wilkinson.
Cubist. April 1 2008 - March 31 2009
Role of yycGF in daptomycin resistance in S. aureus
Brian James Wilkinson.
Cubist Pharmaceutical Co.. January 2008 - March 2011
Intellectual Property
Lactobacillus strain and bacteriocin
United States 8,470,583
Brian James Wilkinson, S Liu, .
Journal Article
Lipidomic and Ultrastructural Characterization of Cell Envelope of Staphylococcus aureus Grown in the Presence of Human Serum
Kell M Hines, Gloria Alvarado, X Chen, Craig Gatto, Antje Pokorny, F Alonzo, Brian James Wilkinson, Libin Xu.
mSphere, 5 (3), 339-355, (2020)
Plasticity of Coagulase-Negative Staphylococcal Membrane Fatty Acid Composition and Implications for Responses to Antimicrobial Agents.
Kiran B Tiwari, Craig Gatto, Brian James Wilkinson.
Antibiotics, 9 (214), 1-10, (2020)
Interrelationships between Fatty Acid Composition, Staphyloxanthin Content, Fluidity, and Carbon Flow in the <i>Staphylococcus aureus</i> Membrane.
K B Tiwari, Craig Gatto, Brian James Wilkinson.
Molecules (Basel, Switzerland), 23 (5), (2018), 10.3390/molecules23051201
Roles of pyruvate dehydrogenase and branched-chain α-keto acid dehydrogenase in branched-chain membrane fatty acid levels and associated functions in Staphylococcus aureus.
V K Singh, S Sirobhushanam, R P Ring, S Singh, Craig Gatto, Brian James Wilkinson.
Journal of medical microbiology, 67 (4), 570-578, (2018), 10.1099/jmm.0.000707
Utilization of multiple substrates by butyrate kinase from Listeria monocytogenes.
S Sirobhushanam, Charitha Srinivas Reddy Galva, L P Saunders, S Sen, Radheshyam Jayaswal, Brian James Wilkinson, Craig Gatto.
Biochimica et biophysica acta, 1862 (3), 283-290, (2017), 10.1016/j.bbalip.2016.12.001
Broad substrate specificity of phosphotransbutyrylase from Listeria monocytogenes: A potential participant in an alternative pathway for provision of acyl CoA precursors for fatty acid biosynthesis.
S Sirobhushanam, C Galva, S Sen, B J Wilkinson, C Gatto.
Biochimica et Biophysica Acta, 1861, 1102-1110, (2016)
Growth-Environment Dependent Modulation of Staphylococcus aureus Branched-Chain to Straight-Chain Fatty Acid Ratio and Incorporation of Unsaturated Fatty Acids.
S Sen, S Sirobhushanam, S R Johnson, Y Song, R Tefft, Craig Gatto, Brian James Wilkinson.
PloS one, 11 (10), e0165300, (2016), 10.1371/journal.pone.0165300
Growth-environment dependent modulation of Staphylococcus aureus branched-chain to straight-chain fatty acid ratio and incorporation of unsaturated fatty acids.
S Sen, S Sirobhushanam, S R Johnson, Y Song, R Tefft, C Gatto, B J Wilkinson.
(2016)
Insights into the Mechanism of Homeoviscous Adaptation to Low Temperature in Branched-Chain Fatty Acid-Containing Bacteria through Modeling FabH Kinetics from the Foodborne Pathogen Listeria monocytogenes.
L P Saunders, S Sen, Brian James Wilkinson, Craig Gatto.
Frontiers in microbiology, 7, 1386, (2016), 10.3389/fmicb.2016.01386
Insights into the mechanism of homeoviscous adaptation to low temperature in branched-chain fatty acid containing bacteria through modelling FabH kinetics from the foodborne pathogen Listeria monocytogenes
L P Saunders, S Sen, B J Wilkinson, C Gatto.
Frontiers in Microbiology, 7, 1386, (2016)
The role of two branched-chain amino acid transporters in Staphylococcus aureus growth, membrane fatty acid composition and virulence.
J C Kaiser, S Sen, A Sinha, B J Wilkinson, D E Heinrichs.
Molecular Microbiology, 102, 850-864, (2016)
utilization of multiple substrates by butyrate kinase from Listeria monocytogenes.
S Sirobhushanam, C Galva, L P Saunders, S Sen, R Jayaswal, B J Wilkinson.
Biochimica et Biophysica Acta, Dec 06 E pub, (2016)
Short branched-chain C6 carboxylic acids result in increased growth, novel 'unnatural' fatty acids and increased membrane fluidity in a Listeria monocytogenes branched-chain fatty acid-deficient mutant.
S Sen, S Sirobhushanam, M P Hantak, P Lawrence, J T Brenna, Craig Gatto, Brian James Wilkinson.
Biochimica et biophysica acta, 1851 (10), 1406-15, (2015), 10.1016/j.bbalip.2015.07.006
Multiple routes to Staphylococcus aureus daptomycin resistance as revealed by comparative genome sequencing and transcriptional profiling
Y. Song, A. Rubio, Radheshyam Jayaswal, J. A. Silverman, Brian James Wilkinson, , , .
PLoS ONE, 8, e58469, (2013)
Studies on the mechanism of telavancin decreased susceptibility in a laboratory-derived mutant
Y. Song, C. S. Lunde, B. M. Benton, Brian James Wilkinson.
Microb. Drug Res., 19, 247-255, (2013)
An antibiotic that inhibits a late step in wall teichoic acid biosynthesis induces the cell wall stress stimulon in Staphylococcus aureus
J Campbell, A K Singh, J Swoboda, M Gilmore, Brian James Wilkinson, S Walker.
Antimicrob. Agents and Chemotherapy, 56, 1810-1820, (2012)
Antimicrobial effect and mode of action of terpeneless cold-pressed Valencia orange essential oil on methicillin-resistant Staphylococcus aureus
A. Muthaiyan, E. M. Martin, S. Natesan, P. G. Crandall, Brian James Wilkinson, S. C. Ricke.
J. Appl. Microbiol., 112, 1020-1033, (2012)
Application of orange essential oil as an antistaphylococcal agent in a dressing model
A. Muthaiyan, D. Biswas, P. G. Crandall, Brian James Wilkinson, S. C. Ricke.
BMC Complement Altern Med, 12, 125, (2012)
Chromatin Immuno-Precipitation Identifies Genes Under Direct VraSR Regulation in Staphylococcus aureus.
M. Sengupta, V. Jain, Brian James Wilkinson, Radheshyam Jayaswal.
Can J Microbiol., 58 (6), 703-8, (2012)
Fatty acids regulate stress resistance and virulence factor production for Listeria monocytogenes
Y. Sun, Brian James Wilkinson, T. J. Standiford, H. T. Akbini, M. X. O'Riordan.
J. Bacteriol., 194, 5274-5284, (2012)
Further insights into the mode of action of the lipoglycopeptide telavancin through global gene expression studies
Y. Song, C. S. Lunde, B. M. Benton, Brian James Wilkinson.
Antimicrob. Agents Chemother., 56, 3157-3164, (2012)
Novel antibacterial polypeptide laparaxin produced by Lactobacillus paracasei NRRL B-50314 via fermentation
S. Liu, Brian James Wilkinson, K. M. Bischott, S. R. Hughes, J. O. Rich, M. A. Cotta.
J. Pet. Environ. Biotechnol., 3, 3, (2012)
Tea tree oil induced transcriptional alterations in Staphylococcus aureus
J. A. Cuaron, S. Dulal, Y. Song, A. K. Singh, C. E. Montelongo, W. Yu, V. Nagarajan, Radheshyam Jayaswal, Brian James Wilkinson, J. E. Gustafson.
Phytother. Res., 10, 1002, (2012)
Alterations in the transcriptome and antibiotic susceptibility of Staphylococcus aureus grown in the presence of diclofenac
J T Riordan, J M Dupre, S A Cantore-Matyi, A Kumar-Singh, Y Song, S Zaman, N S Helal, N Nagarajan, M O Elasri, Brian James Wilkinson, J E Gustafson.
Annal. Clin. Microbiol. Antimicrob., 10, 30, (2011)
Fur is required for the activation of virulence gene expression through the induction of the sae regulatory system in Staphylococcus aureus.
M. Johnson, M. Sengupta, J. Purves, E. Tarrant, P. H. Williams, A. Cockayne, A. Muthaiyan, R. Stephenson, N. Ledala, Brian James Wilkinson, Radheshyam Jayaswal, J. A. Morrissey.
Int. J. Med. Microbiol., 301 (1), 44-52, (2011)
Metabolomes of the psychrotolerant bacterium Listeria monocytogenes 10403S grown at 37 °C and 8 °C.
A. K. Singh, A. V. Ulanov, Z. Li, Radheshyam Jayaswal, Brian James Wilkinson.
Int. J. Food Microbiol., 148 (2), 107-114, (2011)
Synthetic lethal compound combinations reveal a fundamental connection between wall teichoic acid and peptidoglycan biosynthesis in Staphylococcus aureus
J Campbell, A K Singh, J P Santa Maria, Y Kim, S Brown, J G Swoboda, E Mylonakis, Brian James Wilkinson, S Walker.
ACS Chemical Biology, 6, 106-116, (2011)
Transcriptome analysis of alkali shock and alkali adaptation in Listeria monocytogenes 10403S
E S Goitis, A Muthaiyan, Brian James Wilkinson, D A McDowell.
Foodborne Pathogens and Disease, 7, 1147-1157, (2010)
Transcriptomic response of Listeria monocytogenes to iron limitation and fur mutation.
N. Ledala, M. Sengupta, A. Muthaiyan, Brian James Wilkinson, Radheshyam Jayaswal.
Appl. Environ. Microbiol., 76 (2), 406-16, (2010)
FabH selectivity for anteiso branched-chain fatty acid precursors in Low temperature adaptation in Listeria monocytogenes.
A. K. Singh, Y. M. Zhang, K. Zhu, C. Subramanian, Craig Gatto, Z. Li, Radheshyam Jayaswal, C. O. Rock, Brian James Wilkinson.
FEMS Microbiol. Lett., 301 (2), 188-92, (2009)
sarA inactivation reduces vancomycin-intermediate and ciprofloxacin-resistance expression by Staphylococcus aureus
S A Cantore, R Lamichhane-Khadka, J T Riordan, A Delgado, A Norman, S Buenas, S Zaman, S Horan, Brian James Wilkinson, J E Gustafson.
Intl. J. Antimicrob. Agents, 34, 136-141, (2009)
Presentations
Branched-chain amino acids
Brian James Wilkinson.
ASM, Boston, MA, June, 2016
Pyruvate dehydrogenase
Brian James Wilkinson.
ASM, Boston, MA, June, 2016
Growth-medium dependent plasticity of Staphylococcus aureus membrane fatty acid profile and carotenoid content
S Sen, B J Wilkinson.
Annual Meeting, New Orleans, LA, May, 2015
C6 branched-chain carboxylic acids result in increased growth, novel unnatural fatty acids and altered membrane properties in a Listeria monocytogenes branched-chain alpha-keto acid dehydrogenase mutant
S Sen, S Sirobhushnam, L Fernandez-Flores, M P Hantak, C Gatto, Brian James Wilkinson, .
Annual Meeting, Online, May, 2013
Characterization of butyrate kinase from Listeria monocytogenes
S Sirobhushnam, L P Saunders, S Sen, R K Jayaswal, C Gatto, Brian James Wilkinson.
Annual Meeting, Online, May, 2013
Tole of twin-arginine translocase (Tat) system in iron-uptake in Listeria monocytogenes
K B Tiwari, Brian James Wilkinson, R K Jayaswal.
Annual Meeting, Denver, CO, May, 2013
C6-Branched-chain carboxylic acids result in increased growth, novel 'unnatural' fatty acids and altered membrane properties in a Listeria monocytogenes branched-chain keto acid dehydrogenase mutant
Brian James Wilkinson.
Gram-positive Bacterial Pathogens, Omaha, NE, October, 2012
Chromatin immune-precipitation identifies genes under direct VraSR regulation in Staphylococcus aureus
M Sengupta, V Jain, Brian James Wilkinson, Radheshyam Jayaswal.
111th General Meeting of the American Society for Microbiology, New Orleans, LA, , 2011
Studies on the mechanism of decreased susceptibility to telavancin in a laboratory-derived Staphylococcus aureus mutant
Y Song, S R Gill, C S Lunde, B M Benton, Brian James Wilkinson.
Intersci. Conf. Antimicrob. Agents Chemother, Online, , 2011
Cold pressed terpeneless valencia orange oil: a potential topical anti-staphylococcal agent
A Muthaiyan, D Biswas, P G Crandall, Brian James Wilkinson, S C Ricke.
Annu. Mtg. Am. Soc. Microbiol, Online, , 2010
Anti-staphylococcal activity and mode of action of cold pressed terpeneless valencia orange oil
A Muthaiyan, D Biswas, E M Martin, P G Crandall, Brian James Wilkinson, S C Ricke.
Annu. Mtg. Am. Soc. Microbiol., Online, , 2010
Transcriptional profiling of Listeria monocytogenes responses to cold shock and cold acclimation
A Singh, M Julotok, Brian James Wilkinson.
Annu. Mtg. Am. Soc. Microbiol., Online, , 2010
Transcriptional profiling studies of the mode of action of telavancin
Y Song, C S Lunde, B M Benton, Brian James Wilkinson.
Intersci. Conf. Antimicrob. Agents Chemother, Online, , 2010
The Staphylococcus aureus Tea Tree Oil Stimulon
J A Cuaron, S Dulal, J Rivera, V Nagarajan, S Yang, A K Singh, Radheshyam Jayaswal, Brian James Wilkinson, J E Gustafson.
110th General Meeting of the American Society for Microbiology, San Diego, California, May, 2010
The Staphylococcus aureus ethanol stimulon
J M Pando, J Rivera, J A Cuaron, S Yang, A K Singh, W Yu, Brian James Wilkinson, J E Gustafson.
Annu. Mtg. Am. Soc. Microbiol, Online, , 2009
Comparative metabolomics of the psychrotolerant bacterium Listeria monocytogenes 10403S grown at 37˚C and 8˚C
A Singh, Z Li, A V Ulanov, Radheshyam Jayaswal, Brian James Wilkinson.
Annu. Mtg. Am. Soc. Microbiol., Online, , 2009
Comparison of vancomycin stimulons of clonally related clinical vancomycin-susceptible and hetero vancomycin-intermediate Staphylococcus aureus strains
R Lamichhane-Khadka, S Zaman, J Winters, J Cuaron, N Ledala, A K Singh, Y Song, Brian James Wilkinson, J E Gustafson.
Annu. Mtg. Am. Soc. Microbiol., Online, , 2009
Susceptibility of methicillin-resistant and vancomycin-intermediate Staphylococcus aureus to orange essential oils
A Muthaiyan, P G Crandall, Brian James Wilkinson, S C Ricke.
Annu. Mtg. Am. Soc. Microbiol., Online, , 2009
The diclofenac stimulon of Staphylococcus aureus
J M Dupree, S A Matyi, A K Singh, S Yang, S Zaman, S Horan, V Nagarajan, M O Elasri, Brian James Wilkinson, J E Gustafson.
Annu. Mtg. Am. Soc. Microbiol., Online, , 2009
Transcriptomes of daptomycin-resistant Staphylococcus aureus
Y Song, A Rubio, Radheshyam Jayaswal, J A Silverman, Brian James Wilkinson.
Annu. Mtg. Am. Soc. Microbiol., Online, , 2009
Aspects of the regulatory mechanisms in the alkali-tolerance response (ALTR) of Listeria monocytogenes
E S Giotis, A Muthaiyan, I Blair, Brian James Wilkinson, D A McDowell.
Biomicroworld Conference, Lisbon, , 2009
Putative Third Player Identified in VraSR Mediated Regulation of Cell-Wall Associated Genes
Mrittika Sengupta, Vaibhav Jain, Atul Singh, Brian James Wilkinson, Radheshyam Jayaswal.
Gordon Research Conference, Waterville, New Hampshire, , 2009
Chromatin Immunoprecipitation (ChIP) Assays Identify VraSR Regulated Genes in Staphylococcus aureus
Mrittika Sengupta, Vaibhav Jain, V Jain, Atul Singh, Brian James Wilkinson, Radheshyam Jayaswal.
109th General Meeting of the American Society for Microbiology, Philadelphia, PA, May, 2009
β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH) of Listeria monocytogenes has Increased Preference for the Precursor of Anteiso Fatty Acids over Iso Branched-Chain Fatty Acid Precursors at Low Temperature
Mrittika Sengupta, Vaibhav Jain, Atul Singh, Craig Gatto, Radheshyam Jayaswal, C O Rock, Brian James Wilkinson.
109th General Meeting of the American Society for Microbiology, Philadelphia, PA, May, 2009